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If your typical I/O size is larger than your segment size, increase your segment size in order to minimize the number of physical disks needed to satisfy an I/O request. This is especially true in a multi-user, database, or file system storage environment. Using a single physical disk for a single request leaves other physical disks available to simultaneously service other requests.
If you are using the virtual disk in a single-user, large I/O environment (such as for multimedia application storage), performance is optimized when a single I/O request can be serviced with a single data stripe (the segment size multiplied by the number of physical disks in the disk group that are used for I/O). In this case multiple disks are used for the same request, but each disk is only accessed once.